Product Includes
-
Application Dilution
Western Blot 1:500
Immunofluorescence 1: 100-1:200
Immunohistochemistry (Paraffin) 1:50-1:100
Immunofluorescence 1: 100-1:200
Immunohistochemistry (Paraffin) 1:50-1:100
Storage
Store at +4°C for short term storage. Long time storage is recommended at -20°C
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Specificity / Sensitivity
Endogenous
Source / Immunogen
-
Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. [provided by RefSeq, Aug 2020]