Product Includes
Application Dilution
Immunofluorescence 1:200 – 1:500
Immunohistochemistry (Paraffin) 1:100 – 1:300
Storage
100mM Tris Glycine, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Specificity / Sensitivity
Source / Immunogen
This gene encodes a transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]
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Reviews
IR29-77 anti-CD68 antibody WB image
Lysates at 35 μg per lane. This blot was produced using a 5% SDS-PAGE. The gel was run at 140V for 50 minutes before being transferred onto a Nitrocellulose membrane was then blocked for an hour before being incubated with IR29-77 overnight at 4°C.
Anti-CD68 antibody at 1/1000 dilution
IR29-77 anti-CD68 antibody IHC image
Immunohistochemical analysis of paraffin embedded human spleen, liver, tonsil tissue labeling CD68 with IR29-77 at 1/300.
IR29-77 anti-CD68 antibody IHC image
Immunohistochemical analysis of paraffin embedded human placenta and skin tissue labeling CD68 with IR29-77 at 1/300.
IR29-77 anti-CD68 antibody IHC image
Immunohistochemical analysis of paraffin embedded human brain tissue labeling CD68 with IR29-77 at 1/400.