Product Includes
-
Application Dilution
Immunofluorescence 1:100-1:200
Immunohistochemistry (Frozen) 1:50-1:100
Flow Cytometry 1:50-1:100
Immunohistochemistry (Frozen) 1:50-1:100
Flow Cytometry 1:50-1:100
Storage
Phosphate-buffered solution, pH 7.2, containing 0.025% ProClin 300 , 20% Glycerol.
Store at -20°C.
Store at -20°C.
Specificity / Sensitivity
Endogenous
Source / Immunogen
Synthetic peptide / Extracellular domain corresponding to Mouse CD3
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]